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Posts Tagged ‘aids’

HIV Drugs and Multiple AIDS Drug Therapies

Immune system therapies are essentially treatments that help the body by modifying components of the immune system to be more effective. besides drugs a number of therapies are being looked into for use by people with HIV by boosting the body’s immunity.

How HIV medications are combined and the order in which they are given are important factors to consider when designing treatment strategies for patients new to antiretroviral therapy, says a new study funded by the National Institute of Allergy and Infectious Diseases (NIAID), one of the National Institutes of Health. When HIV-infected individuals begin treatment with a combination of the drugs zidovudine, better known as AZT, lamivudine and efavirenz, the drugs retain their effectiveness for a longer period of time than when individuals begin treatment with one of several other three-drug regimens. Highly active antiretroviral therapy (HAART) employs combinations of anti-HIV drugs to help suppress the virus in people with HIV/AIDS. The purpose of HAARt is combined various HIV medications to supress HIV in a multitude of ways. Two types of those that help to stop the virus from duplicating itself, called RT reverse transciptase inhibitors and those that stop it fom being infections, PI. RT inhibitors can be further broken down into nucleoside RT inhibitors, which halt HIV replication by making faulty DNA building blocks, and non-nucleoside inhibitors, which bind to the enzyme reverse transcriptase to prevent the virus from copying itself. The effacacy of HIV drug combinations can decrease over time and doctors have to often implement new combinations. Combination AIDS HIV regimens are our currently most effective method in the fight against HIV/AIDS. Using this regimens we have been able to prolong lives, improve quality of life and even slow the transmission of HIV/AIDS.

 

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HIV Spread and Prevention

Despite substantial advances in the treatment of human immunodeficiency virusAIDS HIV infection, the estimated number of annual new HIV infections in the United States has remained at 40,000 for over 10 years. HIV prevention in this country has largely focused on persons who are not HIV infected, to help them avoid becoming infected. However, further reduction of HIV transmission will require new strategies, including increased emphasis on preventing transmission by HIV-infected persons. HIV-infected persons who are aware of their HIV infection tend to reduce behaviors that might transmit HIV to others. Nonetheless, recent reports suggest that such behavioral changes often are not maintained and that a substantial number of HIV-infected persons continue to engage in behaviors that place others at risk for HIV infection.

Reverting to risky behavior can be as important in the transmission of HIV as the orignal failure to adopt safer sex practices. Unprotected anal sex seems to be happening more often in some urban centers, especially amoung young men who have sex with other men. Bacterial and viral sexually transmitted diseases (STDs) in HIV-infected men and women receiving outpatient care have been increasingly noted, indicating ongoing risky behaviors and opportunities for HIV transmission. Despite the decline in syphilis infection rate in the general U.S. population, sustained outbreaks of syphilis among MSM, many of whom are HIV infected, continue to occur in some areas; rates of gonorrhea and chlamydial infection have also risen for this population. Rising STD rates among MSM indicate increased potential for HIV transmission, both because these rates suggest ongoing risky behavior and because STDs have a synergistic effect on HIV infectivity and susceptibility. Studies suggest that optimism about the effectiveness of highly active antiretroviral therapy (HAART) for HIV may be contributing to relaxed attitudes toward safer sex practices and increased sexual risk-taking by some HIV-infected persons.

Injection drug use also continues to play a key role in the HIV epidemic; at least 28% of AIDS cases among adults and adolescents with known HIV risk category reported to CDC in 2000 were associated with injection drug use. In some drug using communites, HIV seroincidene and seroprevalence in injection drug users has declined recently. This decline has been attributed to several factors, including increased use of sterile injection equipment, declines in needle-sharing, shifts from injection to noninjection methods of using drugs, and cessation of drug use. However, injection-drug use among young adult heroin users has increased substantially in some areas a reminder that, as with sexual behaviors, changes to less risky behaviors may be difficult to sustain.

Clinicians providing medical care to HIV-infected persons can play a key role in helping their patients reduce risk behaviors and maintain safer practices and can do so with a feasible level of effort, even in constrained practice settings. Clinicians can greatly affect patients’ risks for transmission of HIV to others by performing a brief screening for HIV transmission risk behaviors; communicating prevention messages; discussing sexual and drug-use behavior; positively reinforcing changes to safer behavior; referring patients for such services as substance abuse treatment; facilitating partner notification, counseling, and testing; and identifying and treating other STDs. These steps may also help to decreaste a patients’ risks of getting other STDs and bloodborne infections (e.g., viral hepatitis). Managed care plans can play an important role in HIV prevention by incorporating these recommendations into their practice guidelines, educating their providers and enrollees, and providing condoms and educational materials. Prevention services might be delivered in a clinical or office setting or even through referral to community programs. Some clinicians have expressed concern that reimbursement is often not provided for prevention services and note that improving reimbursement for such services might enhance the adoption and implementation of these guidelines.

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Starting HIV Regimens

HIV treatment Basics:

1. Typical starting regimens for treating HIV often include -

-Efavirenz/Zidovudine/Lamivudine

- Efavirenz/Tenofovir/Emtricitabine (Atripla)

- Lopinavir boosted by Ritonavir/Lamivudine/Zidovudine

- Lopinavir boosted by Emtricitabine/Tenofovir/Ritonavir

These can be adjusted based on resistant strains present and your doctor’s recommendations. HAART is a critical aspect to controlling HIV and you should discuss these and other treatment options with your doctor. Using a combination of AIDS drugs will enable you to better control the infection and greatly slow its progression. One diffuclt aspect can be managing the benefits of the HIV medications against the side effects, the side effects can be very severe. This has in recent years been reduced as drug breakthroughs continue to happen.

2. HIV drugs are expensive, know where to go for help

There are many organizations who will send you your medications free or cheaper if you can provide proof that you are low income. Sometimes it can prove fruitful to contact the drug manufacture and sometimes they will give you a lower price. Also depending on your insurance level whether you are uninsured or under insured it sometimes can save you a lot of money to order your medications online.

3. You need to have an active relationship with your doctor

If you want to effectively treat HIV you need a relationship with your doctor so you can get the drug regimens that work for you and all the care you need. Theres no way to avoid this and you should try to engage in many discussions about your treatment.

HIV Information and help can be found on AIDS drugs.

AIDS Drugs Reference sheet for various HIV medications(HIV Medication list) and how to afford them. Also basic HIV information about safe sex, HAART, and various other topics.

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AIDS Basics

AIDS was first reported in the United States in 1981 and has since become a major worldwide epidemic. AIDS is caused by the human immunodeficiency virus, or HIV. By destroying or harming cells of the body's immune system, HIV eventually destroys the body's ability to fight off infection. People diagnosed with AIDS may get life-threatening diseases called opportunistic infections. OI's are caused by viruses and bacteria that don't normally effect someone with a healthy immune system.

HIV Causes AIDS

 

Since 1981, more than 980,000 cases of AIDS have been reported in the United States to the Centers for Disease Control and Prevention (CDC). The CDC reports that 1 million Americans are likily infected with HIV, 1/4 of which are unaware of their infection. The HIV epidemic is increasing the most amoung minority populations and is leading killer of black males between age 25 and 44. According to CDC, AIDS affects nearly seven times more African Americans and three times more Hispanics than whites. In recent years, an increasing number of African-American women and children are being affected by HIV/AIDS.

HIV destroys CD4 positive (CD4+) T cells, which are white blood cells crucial to maintaining the function of the human immune system. As the virus attacks those cells, the person infected with HIV is less equipped to fight off infection and disease ultimately resulting in the development of AIDS.

Often people who have HIV take a long time to develope AIDS because their immune systems can fight the virus for a period of time. There is a strong connection between HIV in the blood and the decline of CD4 cells and the onset of AIDS. Antiretroviral medicines can reduce the amount of virus in the body, preserve CD4+ T cells and dramatically slow the destruction of the immune system.

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What Begining HIV Treatment is Like

Each HIV infected patient who is entering into care should have a full medical history, physical, lab evaluation and counseling. This is to confirm the presenence of HIV, get historical and laboratory data, discuss treatment of HIV with patient, and initiate care as suggested by HIV primary care guidelines. Baseline data then is utilized to define management goals and future plans.

A new patient should have the following tests performed on them in their first visits

•  HIV antibody testing (if prior documentation not available) or if HIV RNA is undetectable (AI);
•  CD4 T-cell count (AI);
– HIV RNA (Viral Load);
•  Complete blood count, chemistry profile, transaminase levels, BUN and creatinine, urinalysis, screening test
for syphilis (e.g., RPR, VDRL, or treponema EIA), tuberculin skin test (TST) or interferon-γ release assay
IGRA (unless there is history of a prior TB or positive TST or IGRA), anti Toxoplasma gondii IgG,
hepatitis A, B, and C serologies, and Pap smear in women;
• Fasting blood glucose and serum lipids if the patient is considered at risk for cardiovascular disease and for
baseline evaluation before the start of ARV therapy and
• For patients who have pretreatment HIV RNA >1,000 copies/mL, genotypic resistance testing when the
patient enters into care, regardless of whether therapy will be initiated immediately (AIII). For patients who
have HIV RNA levels of 500–1,000 copies/mL, resistance testing also may be considered, even though
amplification may not always be successful (BII). If therapy is deferred, repeat testing at the time of
antiretroviral initiation should be considered (CIII).

People living with HIV/AIDS must often deal with several social, psychiatric, and health related issues that are best
adressed with a multidisciplinary approach to HIV. The evaluation also must include assessment of
substance abuse, economic factors (e.g., unstable housing), social support, mental illness, comorbidities, high-risk behaviors, and other factors that are known to impair the ability to adhere to treatment and to promote education about HIV Once evaluated, these factors should be managed accordingly.
Lastly,  risk behaviors and effective strategies to prevent HIV transmission. to others should be
provided at all a patient’s clinical visits.

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So You Have HIV

Get Healthy, Eat The Right Way

Get Healthy, Eat The Right Way

It is a dangerous time to live in. Although we the human being have come along way since the days of medieval weapons and torture, we now have to grapple with risk of invisible death. There are so many diseases that pop up every now and then and it gets worse. Scientists work hard to try and discover better treatment and cures, but we never seem to catch up. One of the worst, and the king of all virus is the HIV Aids. This deadly virus invades the body in the form of HIV, but as time progresses, it eventually develops into the AIDS. All human beings must acquire HIV information in some way or another and understand the symptoms of hiv in order to better prevent this epidemic from spreading.

Our schools teach us the horrors of AIDS. HIV information is provided to us by the time we graduated into high school. While many teens took this as warning in not hving sex at early age, the real important message is actually to stay alive. We all want our children to know and understand the dangers of HIV Aids symptoms, the virus that causes AIDS which is not curable at this moment. The best HIV information I was given involve on how the was the virus was contracted. HIV can be transmitted through many channels such as such as unprotected sex, mother to child during pregnancy, intravenous drug use, and breast feeding. These are some of the most common ways to get infected with HIV. As many already know, the most common form of infection is sex. There are many ignorant people that still have unprotected sex casually. This is just strange as considering how easy it is to put on a condom in the first place.

An abundance of data on HIV can be found on various websites. This is a great way to help people become better informed about this deadly virus. It is hard to ignore the statistics of AIDS today. Far too many have this deadly virus. It is imperative to understand that there is no cure for this disease at all. There are expensive medcines and good treatment, but if contracted with HIV, your life will be changed forever. Whether it’s through books or the Internet, go cquire essential HIV information today. The best way is to prevent it altogether. If you are sexually active with many partners, it is always a good idea to get tested for HIV regularly.

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